The frequency of the G alleles was significantly higher in women with preeclampsia than in controls (51.1% vs. 42.0%; OR 1.44, p<0.043). Women with placental abruption had decreased frequency of AA genotype (22.2% vs. 35.7%) and significantly more AG or GG genotypes compared with controls (OR 1.94, p<0.024) [R].

The A/A genotype and the ''A'' allele increased the risk of developing hepatitis B virus (HBV)-related hepatocellular carcinoma (HCC) [R].

AA vs GG variant genotype was associated with increased risk of 1.43-fold for hepatocellular carcinoma (HCC), and 1.66-fold for cervical cancer [R]. 

The frequency of the G allele was higher in late acute rejection in patients undergoing kidney transplant (p=0.013, OR=2.02) [R].

G/A polymorphism is associated with increased risk of pancreatic cancer. AA genotype (OR=1.32, p=0.029) and the ''A'' allele (OR=1.47, p=0.033) were higher in pancreatic cancer patients than in controls [R].

AA genotype and the ''A'' allele were significantly increased in patients with osteosarcoma compared to healthy controls (OR 2.27, p=0.010, and OR 1.41, p=0.015) [R].

AA genotype was overrepresented in patients with urinary schistosomiasis (p=0.007), while the GG genotype (p=0.029) was significantly decreased in the patients with schistosomiasis [R].

The frequency of delayed graft function (DGF) was higher in the individuals with the G allele compared with the carriers of the A allele (GG+AG vs. AA, OR 1.80; p=0.05) [R].

The frequencies of G allele was significantly increased in primary biliary cirrhosis (PBC) patients when compared with normal controls (P < 0.001, odds ratio = 1.44) [R]. 

The G allele carriers (GG+GA) might have an increased risk of Graves' disease (GD) when compared with the AA homozygote carriers (GG+GA vs. AA: OR = 2.57) [R].

AA genotype and A allele were significantly increased in Ewing's sarcoma (ES) patients compared to controls (OR=2.03, 95%, p=0.018; and OR=1.33, p=0.027) [R].

The G allele is a risk factor associated with increased type 1 diabetes (T1D) susceptibility [R]. 

The minor allele G carried estimated relative risk of 1.39 (95 % CI 1.11-1.74) for latent autoimmune diabetes in adults (LADA) [R].

A significantly increased colorectal cancer (CRC) risk is attributed to the AG genotype as compared to the AA genotype (OR: 1.17 for AG vs AA) [R]. 

A allele was associated with significantly higher rate of spontaneous viral clearance in anti-HCV F antibody negative patients (adjusted OR=0.512, P=0.008) [R].

'GG' genotype was significantly higher in patients with systemic lupus erythematosus (SLE) (12.32%) than those in healthy control subjects (4.6%) (OR: 1.797; p=0.001) [R].



Parent Gene: CTLA4

Importance: 3
Less common allele: G = 43%
More common allele: A = 57%
My Genotype: Log In