The G (minor) allele is associated with:

  • One G= more insulin resistance, causing increased risk of type-2 diabetes (OR=1.17).
  • Increased risk of early-onset T2D (OR 1.32).
  • TRIB3 is induced by the transcription factor NF-kappaB.
  • TRIB3 disrupts insulin signaling by binding directly to Akt kinases and blocking their activation.

rs2295490

Parent Gene: TRIB3

Importance: 3
Less common allele: G = 20%
More common allele: A = 80%
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