rs2288774 is a SNP in the NEDD4L gene and has been associated with hypertension.

Carriers of the CC- or CT-genotype had significantly higher systolic blood pressure (SBP) than carriers of the TT-genotype [R].

Carriers of the CC genotype had significantly higher salt sensitivity (median, IQR) (18.0, 7.5-20.0 mmHg vs 6.0, 0.0-10.0 mmHg, P = 0.007) and lower plasma renin concentration (P-renin) (6.0, 2.0-9.5 mU/L vs 15.0, 9.0-24.0 mU/L, P = 0.005) as compared to non-carriers of these genotypes [R].


Parent Gene: NEDD4L

Importance: 2
Less common allele: C = 49%
More common allele: T = 51%
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