rs2275913, also known as G-197A, is a SNP in the IL17A gene.

A study of 811 Japanese subjects (524 without gastric cancer and 287 with gastric cancer) reported an odds ratio of 1.42 (CI: 1.09-1.85, p=0.01) for the rs2275913(A) allele, and 3.02 (CI: 1.86-4.91, p<0.0001) for the (A;A) genotype, with gastric cancer.[PMID 19414056]

[PMID 19724898] Effect of polymorphisms of IL-17A, -17F and MIF genes on CpG island hyper-methylation (CIHM) in the human gastric mucosa

[PMID 20437253] The Polymorphism of IL-17 G-152A was Associated with Childhood Asthma and Bacterial Colonization of the Hypopharynx in Bronchiolitis

This "A"-allele of this SNP is also functionally associated with acute Graft-Versus-Host Disease after unrelated bone marrow transplantation 10.1371/journal.pone.0026229[PMID 22028838] A Genetic Variant in the IL-17 Promoter Is Functionally Associated with Acute Graft-Versus-Host Disease after Unrelated Bone Marrow Transplantation

[PMID 22118860] Interleukin 17 gene polymorphism is associated with anti-aquaporin 4 antibody-positive neuromyelitis optica in the Southern Han Chinese - A case control study

[PMID 22483685] Interactions between IL17A, IL23R, and STAT4 polymorphisms confer susceptibility to intestinal Behcet's disease in Korean population

[PMID 22461912] Association Analysis of IL-17A and IL-17F Polymorphisms in Chinese Han Women with Breast Cancer

[PMID 17828618] The influence of polymorphisms of interleukin-17A and interleukin-17F genes on the susceptibility to ulcerative colitis.

[PMID 19208686] Association analysis of the interleukin 17A gene in Caucasian rheumatoid arthritis patients from Norway and New Zealand.

[PMID 19235914] Genetic epistasis of IL23/IL17 pathway genes in Crohn's disease.

[PMID 20620187] Interleukin-17 gene polymorphism is associated with Vogt-Koyanagi-Harada syndrome but not with Behcet's disease in a Chinese Han population.

[PMID 21217785] A single nucleotide polymorphism of IL-17 gene in the recipient is associated with acute GVHD after HLA-matched unrelated BMT.

[PMID 22692973] Interleukin-17 gene polymorphisms are associated with bladder cancer in a Chinese Han population.

[PMID 23049595] Association between IL17 Polymorphisms and Risk of Cervical Cancer in Chinese Women

[PMID 23131423] Interleukin-17A genetic variants can confer resistance to brucellosis in Iranian population

[PMID 23376081] Analysis of IL-17 gene polymorphisms in Chinese patients with dilated cardiomyopathy

[PMID 23652560] Genetic polymorphisms of interleukin 17A and interleukin 17F and their association with inflammatory bowel disease in a Chinese Han population

[PMID 23137879] Evaluation of IL17A expression and of IL17A, IL17F and IL23R gene polymorphisms in Brazilian individuals with periodontitis

[PMID 23485736] Polymorphisms in immune/inflammatory cytokine genes are related to Parkinson's disease with cognitive impairment in the Han Chinese population

[PMID 24315816] Effect of interleukin-17A and interleukin-17F gene polymorphisms on the risk of gastric cancer in a Chinese population

[PMID 22537748] Genetic polymorphisms of IL17A and pri-microRNA-938, targeting IL17A 3'-UTR, influence susceptibility to gastric cancer.

[PMID 22559912] Increased activity of interleukin-23/interleukin-17 cytokine axis in primary antiphospholipid syndrome.

[PMID 22816799] Association of interleukin-17A and -17F gene single-nucleotide polymorphisms with autoimmune thyroid diseases.

[PMID 22955700] Influence of IL17A polymorphisms (rs2275913 and rs3748067) on the susceptibility to ulcerative colitis.

[PMID 23219503] The IL-17F sequence variant is associated with susceptibility to tuberculosis.

[PMID 23280722] IL17A gene polymorphisms, serum IL-17A and IgE levels, and hepatocellular carcinoma risk in patients with chronic hepatitis B virus infection.

[PMID 23778030] The IL-17 G-152A single nucleotide polymorphism is associated with pulmonary tuberculosis in northern Spain.

[PMID 24857622] IL-17F but not IL-17A gene polymorphism confers risk to multiple sclerosis in a Chinese Han population

[PMID 24919468] Influence of the IL17A locus in giant cell arteritis susceptibility

[PMID 25012243] IL-17 gene polymorphism is associated with susceptibility to gastric cancer

[PMID 25227691] Association of IL-17A and IL-17 F gene polymorphisms with recurrent pregnancy loss in Iranian women

[PMID 25374195] Meta-analysis of Associations between Interleukin-17 Gene Polymorphisms and Risk of Gastric Cancer

[PMID 25680555] Interleukin-17FT7488 allele is associated with a decreased risk of colorectal cancer and tumor progression

[PMID 25857634] Genetic Polymorphisms in the Toll-like Receptor 10, Interleukin (IL)17A and IL17F genes differently affect the risk for Tuberculosis in Croatian population

[PMID 25871515] Association between interleukin 17A polymorphisms and susceptibility to rheumatoid arthritis in a Chinese population

[PMID 25595174] Specific association of IL17A genetic variants with panuveitis

[PMID 26339129] The Influence of Interleukin 17A and IL17F Polymorphisms on Chronic Periodontitis Disease in Brazilian Patients

[PMID 26337284] Association study between IL-17A and IL-17F gene polymorphism and myasthenia gravis in Chinese patients

[PMID 26400516] Interleukin-17 gene polymorphisms in patients with post-transplant diabetes mellitus

[PMID 26436389] Correlation between polymorphisms in the IL-17A and IL-17F genes and development of coronary artery disease

[PMID 26447633] Influence of the IL17A and IL17F genes polymorphisms on the long-term kidney allograft function and return to dialysis after kidney transplantation

[PMID 26467330] Interleukin-17 and leptin genes polymorphisms and their levels in relation to recurrent pregnancy loss in Egyptian females

[PMID 24776844] Associations between functional polymorphisms in the NFκB signaling pathway and response to anti-TNF treatment in Danish patients with inflammatory bowel disease

[PMID 26515887] Interleukin-17A rs2275913, Interleukin-17F rs763780 and rs2397084 gene polymorphisms as possible risk factors in Juvenile lupus and lupus related nephritis

[PMID 26535650] Role of IL-17 gene polymorphisms in the susceptibility to gastric cancer

[PMID 26535675] Association analysis of rs2275913G>A and rs763780T>C interleukin 17 polymorphisms in Chinese women with cervical cancer

[PMID 26546176] Association of IL-17A and IL-17F gene polymorphisms with chronic hepatitis B and hepatitis B virus-related liver cirrhosis in a Chinese population: A case-control study


Parent Gene: IL17A

Importance: 1
Less common allele: A = 29%
More common allele: G = 71%
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