The Minor "A" allele is associated with:

  • AG is the most empathetic version (IRI=70.8), while GG and AA were equal in total empathy (~65.4).
  • In cognitive empathy (putting yourself in someone else's situation), AG (35.9) was the highest followed by GG (34.2) and AA (32.8) (R).
  • Decreased risk of autism
  • Decreased risk of depression and separation anxiety.
  • Amygdala volume increase in both White and Asian populations (R).

The Major "G" allele is associated with:

  • A lesser empathic concern to their partner's distress in romantic relationships (GG).
  • Lower social reciprocity in a support-giving interaction (GG) (R).
  • Decreased attendance to their partner's communication and decreased focus on providing support (GG) (R).

rs2254298

Parent Gene: OXTR

Importance: 4
Less common allele: A = 21%
More common allele: G = 79%
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