Mechanism:

  • Increased transcription of nitric oxide synthase gene (G) [R]

  • Decreased transcription of nitric oxide synthase gene (A) [R]

The Minor "A" allele is associated with:

  • More frequent instances of age-related muscle degeneration among smokers [R]

  • Delayed fracture healing [R]

  • Fewer instances of Parkinson’s disease among smokers [R]

The Major "G" allele is associated with:

  • More frequent instances of Parkinson’s disease among smokers [R]

  • Fewer instances of age-related muscle degeneration among smokers [R]

  • Faster fracture healing [R]

This SNP is associated with (unknown which alleles):

  • Increased susceptibility to tuberculosis in African Americans [R]

rs2248814

Parent Gene: NOS2

Importance: 2
Less common allele: A = 27%
More common allele: G = 73%
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