Mechanism:

  • Lower levels of DRD2 because of change in regulatory region of gene. This makes dopamine have more of an effect on the brain (G) (R).
  • Normal levels of DRD2 protein in the body (A) (R).

The Minor "G" allele is associated with:

  • Increased risk of migraines (R)
  • Improved response to haloperidol (R)
  • Increased risk of smoking at younger ages (R)

The Major "A" allele is involved with:

  • Increased risk of schizophrenia (R)
  • Increased risk of depression (R)
  • Less openness to new experiences (R)
  • Increased risk of nephropathy (R)

rs2242592

Parent Gene: DRD2

Importance: 3
Less common allele: G = 50%
More common allele: A = 50%
My Genotype: Log In