rs2242446 is linked to the SLC6A2 gene. It is significantly associated with major depression.
T/C polymorphism was found to be associated with panic disorder (p < 0.01) [R].
T/C was associated with recurrent depression (OR = 4.15) [R].
''C'' allele carriers had smaller hippocampal volumes relative to other genotypes [R].
Panic disorder patients treated with Serotonin/norepinephrine reuptake inhibitor (SNRI) with only non-C carrier TT genotype showed significantly reduced Panic Disorder Severity Scale (PDSS) scores [R].
The "C" allele is associated with higher blood pressure whilst exercising [R].