rs2242446 is linked to the SLC6A2 gene. It is significantly associated with major depression.

T/C polymorphism was found to be associated with panic disorder (p < 0.01) [R].

T/C was associated with recurrent depression (OR = 4.15) [R].

''C'' allele was associated with greater blood pressure (BP) response to exercise in humans [R].

''C'' allele carriers had smaller hippocampal volumes relative to other genotypes [R].

Panic disorder patients treated with Serotonin/norepinephrine reuptake inhibitor (SNRI) with only non-C carrier TT genotype showed significantly reduced Panic Disorder Severity Scale (PDSS) scores [R]. 

The "C" allele is associated with higher blood pressure whilst exercising [R].


Parent Gene: SLC6A2

Importance: 2
Less common allele: C = 25%
More common allele: T = 75%
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