- Also known as Val12Met, the SNP is in the ABCG2 gene. The (G) allele encodes the Val.
- T (minor) allele is associated with lower levels of ABCG2 protein in body (R).
The T (minor) allele is associated with:
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Increased activity of the drug Pravastatin in patients being treated for hyperlipidaemia (R).
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Increased risk of tophaceous gout (R). This results in joint pain and arthritis.
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Possible increase in drug-induced toxicity (R).
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An increased survival rate in patients undergoing chemotherapy to treat Acute Myeloid Leukemia (R).
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Increased chance of toxic response following chemotherapy to treat Acute Myeloid Leukemia (R).
The C (major) allele is associated with:
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Higher resistance to imatinib therapy in chronic myeloid leukemia patients (CC) (R).