• Also known as Val12Met, the SNP is in the ABCG2 gene. The (G) allele encodes the Val.
• T (minor) allele is associated with lower levels of ABCG2 protein in body (R).

The T (minor) allele is associated with:

• Increased activity of the drug Pravastatin in patients being treated for hyperlipidaemia (R).

• Increased risk of tophaceous gout (R). This results in joint pain and arthritis.

• Possible increase in drug-induced toxicity (R).

• An increased survival rate in patients undergoing chemotherapy to treat Acute Myeloid Leukemia (R).

• Increased chance of toxic response following chemotherapy to treat Acute Myeloid Leukemia (R).

The C (major) allele is associated with:

• Higher resistance to imatinib therapy in chronic myeloid leukemia patients (CC) (R).