- The SNP is found on exon 35 of the ABCA1 gene. It causes an amino acid change from Arginine (major) to Lysine (minor).
The T (minor) allele is associated with:
- Increased levels of total cholesterol (R), but no increased risk of Cardiovascular disease (R).
- Lower levels of LDL-cholesterol in women (R).
- The T allele was found more commonly in male schizophrenia patients (R). This suggests that the T allele may increase risk of developing schizophrenia.
- Possible increased risk of Alzheimer’s disease (R). Some studies have not seen this association.