The Minor "T" allele is associated with:
- Increased risk of cardiovascular disease and coronary artery disease (R).
- Increased risk of obesity and being overweight (R).
- Lower levels of HDL cholesterol (TT) (R) (R).
- Increased risk of abdominal aortic aneurisms (R). The T allele (especially TT) may be a risk factor for the disease.
- Increased risk of developing Type 2 diabetes (R).
- Increased risk of Atherosclerosis (R).
- Possible slight increased risk of developing Alzheimer’s disease (R) (R). Other studies did not find this association.
The C (major) allele is associated with:
- Increased fat intake and increased Triglycerides levels (R).