- T allele (minor)= 2x decreases of binding of AgRP to MC4R, resulting in decreased hunger and increased satiety. This SNP is associated with appetite regulation, obesity, and metabolic syndrome (R).
The Minor "T" allele is associated with:
- Decreased waist circumference in Whites.
- Decreased blood sugar levels.
- Increase in good cholesterol levels (R).
- Decreased risk of metabolic syndrome (R). TT and TC were found to be 2X less likely to have metabolic syndrome than CC (R).
- T carriers are slightly leaner than C carriers (R).
- This SNP is the most prevalent form of single gene-obesity and is responsible for 2% of obesity cases (R), including childhood obesity (R).
- In patients with schizophrenia taking antipsychotic medications, this SNP was found to contribute to the higher prevalence of obesity and metabolic diseases (R R2).
- The SNP could have implications for the cause of polycystic ovary syndrome (PCOS) (R).