rs2228000 may contribute to the recurrence risk of squamous cell carcinoma of the oropharynx (SCCOP) (HR = 1.6) [R]. 

rs2228000 (no reported alleles) had a significant effect on lung cancer survival especially in stage III-IV patients treated with platinum-based chemotherapy without surgical operation [R].

When compared to the ''GG'' genotype subjects carrying ''GA+AA'' genotypes had a 1.57-fold increased risk of lung cancer in a Chinese population [R].

The ''A'' allele had a susceptible association for Hodgkin lymphoma [R].

The ''GA'' and ''AA'' genotypes had a decreased risk of melanoma (OR= 0.15; p < 0.001) [R].



Parent Gene: XPC

Importance: 2
Less common allele: A = 23%
More common allele: G = 77%
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