rs2200733 is linked to the MIR297 and PITX2 genes. It is significantly associated with stroke and atrial fibrillation (AF).
A significant association between the ''T'' allele and patients with Atrial fibrillation (AF) and atrial flutter (AFL) was observed (allelic p<0.001 with OR = 2.17) [R].
Carriers of the''T'' allele had an increased risk of postoperative atrial fibrillation (AF) with preoperative β blocker (BB) (OR 1.47, for those taking a BB, and OR 1.13, for those not taking a BB) [R].
The ''T'' allele favored increased number of episodes of atrial fibrillation (AF) per month (p = 0.045) and larger pulmonary vein diameter (recessive model, p = 0.032) [R].
Patients with the CC genotype exhibited a 0.45 times higher risk of developing atrial fibrillation (AF) than those with the TT genotype (p = 0.02) [R].
Carriage of the ''T'' allele (CT or TT genotype) was more common in patients with lone (39%) than typical (25%) atrial fibrillation (AF) or controls (21%, p <0.01 for both comparisons) [R].
The T/T genotype and the ''T'' allele were detected more frequently in patients with AF compared to controls (13.2% vs. 2.3%, p=0.001, and 29.6% vs. 17.9%, p=0.001) in a greek population [R].