Mechanism:

  • rs2073658 a borderline association with metabolic syndrome was observed, the minor allele being the risk-increasing allele.
  • The minor allele of rs2073658 also associated with higher total and LDL-cholesterol, apolipoprotein B-100 and lipoprotein(a) concentrations in longitudinal analyses [R].

The T allele is associated with:

  • Familial combined hyperlipidemia in Mexicans [R]. 
  • Risk of cardiovascular disease of women in two prospective studies [R].

rs2073658

Parent Gene: USF1

Importance: 3
Less common allele: T = 17%
More common allele: C = 83%
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