Mechanism:

  • G allele higher levels of mRNA [R]

The A major allele is associated with: 

  • protection against noise induced hearing loss (R). 
  • Higher risk of Alzheimer’s disease in Polish population [R].

The G minor allele is associated with: 

  • Protection against Alzheimer’s Disease (R). 
  • Lower risk of brain malformations (myelomeningocele) in HIspanic population [R].

  • Higher risk of liver injury induced by Antituberculosis drugs [R].

rs2070424

Parent Gene: SOD1

Importance: 1
Less common allele: G = 25%
More common allele: A = 75%
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