[PMID 19644876] Association of STAT4 and BLK, but not BANK1 or IRF5, with primary antiphospholipid syndrome

[PMID 17393452] Structural insertion/deletion variation in IRF5 is associated with a risk haplotype and defines the precise IRF5 isoforms expressed in systemic lupus erythematosus.

[PMID 17412832] Three functional variants of IFN regulatory factor 5 (IRF5) define risk and protective haplotypes for human lupus.

[PMID 17476532] Genetic association of IRF5 with SLE in Mexicans: higher frequency of the risk haplotype and its homozygozity than Europeans.

[PMID 18050197] Association of an IRF5 gene functional polymorphism with Sjogren's syndrome.

[PMID 18200047] IFN-regulatory factor 5 gene variants interact with the class I MHC locus in the Swedish psoriasis population.

[PMID 18285424] Interferon regulatory factor 5 (IRF5) gene variants are associated with multiple sclerosis in three distinct populations.

[PMID 18668568] Association of the IRF5 risk haplotype with high serum interferon-alpha activity in systemic lupus erythematosus patients.

[PMID 18843782] Different genetic effects of interferon regulatory factor 5 (IRF5) polymorphisms on systemic lupus erythematosus in a Korean population.

[PMID 19116668] Validating discovered Cis-acting regulatory genetic variants: application of an allele specific expression approach to HapMap populations.

[PMID 19838195] A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus.

[PMID 20080916] Promoter insertion/deletion in the IRF5 gene is highly associated with susceptibility to systemic lupus erythematosus in distinct populations, but exerts a modest effect on gene expression in peripheral blood mononuclear cells.

[PMID 20639879] Variants at IRF5-TNPO3, 17q12-21 and MMEL1 are associated with primary biliary cirrhosis.

[PMID 21952918] Evidence for gene-gene epistatic interactions among susceptibility loci for systemic lupus erythematosus.

[PMID 23392701] Association of rs10954213 polymorphisms and haplotype diversity in interferon regulatory factor 5 with systemic lupus erythematosus: A meta-analysis

[PMID 25036352] Association between IRF5 polymorphisms and autoimmune diseases: a meta-analysis

[PMID 24116155] Two functional variants of IRF5 influence the development of macular edema in patients with non-anterior uveitis

[PMID 26294277] Genetic association and interaction between the IRF5 and TYK2 genes and systemic lupus erythematosus in the Han Chinese population


Parent Gene: IRF5

Importance: 1
Less common allele: C = 6%
More common allele: T = 94%
My Genotype: Log In