rs2066826 (no reported alleles) was significantly associated with a higher prevalence of T2DM (Type 2 diabetes mellitus) [R]. 

The ''T'' allele was found more frequently in the cancer patient group than in the controls. Patients who smoked and had the ''TC'' or ''TT'' genotype had an increased risk of 2.21 for developing lung cancer [R]. 

Subjects carrying the ''T'' allele had significantly lower coronary calcified plaque (P= 0.04). While subjects homozygous for the ''T'' allele had increased carotid calcified plaque (P=0.014) [R].



Parent Gene: PTGS2

Importance: 2
Less common allele: T = 19%
More common allele: C = 81%
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