A study of 577 cases of testicular germ cell tumors, the most common testicular cancer in young men, concluded that the rs2059693(T) allele increased risk. Among Caucasians, the odds ratio for the rs2059693(C;T) genotype was 1.33 (CI: 1.04-1.71), and for the (T;T) genotype, 1.60 (CI: 1.01-2.52, p(trend) = 0.008). The association with rs2059693 was even stronger for nonseminomas, and for teratomas and teratocarcinomas in particular (N = 58; (C;T) odds ratio 1.63, CI: 0.89-2.99; (T;T) odds ratio 4.54, CI: 2.00-10.3, p(trend) = 0.0008).[PMID 18413775]

rs2059693

Parent Gene: INHA

Importance: 1
Less common allele: T = 34%
More common allele: C = 66%
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