The Minor "G" allele is associated with:

  • Each G-allele is associated with 30% higher levels of Brain natriuretic peptide (BNP) in the blood (P<0.0001) (R).
  • Reduced rate of cardiovascular readmission (p<0.0001) [R].
  • Lower BNP 90-year-old men (BNP is a marker of heart failure) [R]. In patients hospitalized for acute Heart Failure, higher BNP values either at admission or at discharge is associated with worse outcomes (R).
  • GG may cause more severe kidney problems (stenosis). GG allele occurred more frequently in patients with high-grade kidney hypertension/stenosis (blood vessel narrowing) [R].

 

rs198389

Parent Gene: NPPB

Importance: 3
Less common allele: G = 36%
More common allele: A = 64%
My Genotype: Log In
Risk Allele: G, G

Disease/Trait: Bnp Measurement

The G allele of rs198389 is reported to be associated with Bnp Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with B-type natriuretic peptide.

Disease/Trait: Cardiovascular Disease Biomarker Measurement

The G allele of rs198389 is reported to be associated with Cardiovascular Disease Biomarker Measurement . Your genotype was not identified for this SNP so we are unable to comment on your association with NT-proBNP levels in acute coronary syndrome.