Mechanism

  • Hypoxia-inducible factor A (HIF1A) allows cells that are low in oxygen to get more oxygen (R). The consequence of the SNP is the protein is made in higher amounts.

The Minor "T" allele is associated with:

  • Increased risk of prostate cancer (R).
  • Increased risk of breast cancer (R).
  • Increased chance of seizures coming back (R).
  • Partial epilepsy (R).
  • Increased risk of Hodgkins Lymphoma, a B-cell cancer (R).
  • Ulcerative Colitis (R).
  • Multiple Sclerosis (R).
  • Amyotrophic Lateral Sclerosis (ALS) (R).
  • Increased blood IgE (R).
  • Being taller as an adult (R).
  • Improved hearing (R).
  • Crohns Disease (R).
  • Protection against prion diseases like vCJD and Kuru (R).
  • Protection from Flucloxacillin-induced liver injury (R).

The Major "C" allele is associated with:

  • Heart disease among Caucasians (R).
  • Diabetes (R).
  • Asthma (R).
  • Higher BMI (R).
  • Higher cholesterol in the blood (R).
  • Higher systolic blood pressure (R).
  • Lowered amount of air you can forcibly breathe out (R).
  • Lowered lung function (R).

rs1957757

Parent Gene: HIF1A

Importance: 4
Less common allele: T = 33%
More common allele: C = 67%
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