The ''T'' allele was positively associated with treatment response (p = 0.0190; OR 1.537) in patients with chronic hepatitis C [R].

The ''G'' allele was associated with an increased risk of ischemic stroke (IS) with an odds ratios (OR) of 1.358 (P = 0.002) [R].

The allele ''T'' confers a 1.47-fold increased risk of developing tuberculosis (TB) (P = 0.0001, OR  = 1.47) [R].

The individuals carrying TG/GG genotype of G/T polymorphism were associated with an increased asthma risk in recessive model (OR = 1.278) [R].

The ''G'' allele is significantly associated with onset of depression in patients previously exposed to stressful-life events [R].

The ''G'' allele was associated with an increased risk of late onset Alzheimer's disease (LOAD) (odds ratios/OR=1.56, P=0.04) [R]. 

Age at rheumatoid arthritis (RA) diagnosis was lower in carriers of the ''GG'' genotype [R].

''GG'' genotype was significantly associated with higher tumor size (p = 0.001), grade (p = 0.030), T (p = 0.001), M (p = 0.012), and stage (p = 0.002) in renal cell carcinoma patients [R]. 

Ischemic stroke (IS) susceptibility of ''G'' carriers increased 1.6 times (OR = 1.601, P = 0.006) compared to T carriers [R].


Parent Gene: IL18

Importance: 2
Less common allele: T = 41%
More common allele: G = 59%
My Genotype: Log In