rs1927914 is a SNP of the TLR4 gene. It is significantly associated with increased diabetic foot ulcer (DFU) risk and other complications in patients with type 2 diabetes mellitus (T2DM) [R].
A positive association was found between asthma severity and the AA genotype indicating that the ''G'' allele has a protective effect on asthma severity (P = .024) [R].
''G'' allele carriers and the ''G'' allele were probably related to a decreased risk of Parkinson's disease (PD) (p = 0.032 and p = 0.028, respectively) male PD (p = 0.034) as well as early-onset PD (EOPD) (p = 0.023) [R].
The minor allele ''G'' showed consistent protective effect against the risk of developing late-onset Alzheimer's disease (LOAD) [R].
Allele ''G'' is associated with a significantly increased risk of normal tension glaucoma (NTG) [R].