rs1927914 is a SNP of the TLR4 gene. It is significantly associated with increased diabetic foot ulcer (DFU) risk and other complications in patients with type 2 diabetes mellitus (T2DM) [R].

A positive association was found between asthma severity and the AA genotype indicating that the ''G'' allele has a protective effect on asthma severity (P = .024) [R].

''G'' allele carriers and the ''G'' allele were probably related to a decreased risk of Parkinson's disease (PD) (p = 0.032 and p = 0.028, respectively) male PD (p = 0.034) as well as early-onset PD (EOPD) (p = 0.023) [R]. 

A significantly higher frequency of the ''G'' allele was observed in patients with type 2 diabetes than in controls, and in patients with diabetic retinopathy (DR) [RR1].

The minor allele ''G'' showed consistent protective effect against the risk of developing late-onset Alzheimer's disease (LOAD) [R].

Allele ''G'' is associated with a significantly increased risk of normal tension glaucoma (NTG) [R].

 

rs1927914

Parent Gene: TLR4

Importance: 2
Less common allele: G = 49%
More common allele: A = 51%
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