The minor allele ''A'' was associated with a lower risk of myocardial infarction (MI) (odds ratio 0.88) [R].

GG genotype (ORadj=6.68) and the AG genotype (ORadj=2.73) increased the risk of prostate cancer (PC) [R]. 

AA genotype influences the susceptibility to adverse effects of traffic-related air pollution on childhood asthma (OR 4.4) [R]. 

Women with pelvic inflammatory disease (PID) who carried the GG genotype had significantly increased odds of C. trachomatis (OR, 3.7; P = .002) [R]. 

Individuals with the minor allele ''A'' had a 1.47- to 1.65-fold increased risk of normal tension glaucoma (NTG) [R].

Carriers of at least 1 minor allele ''A'' were consistently at an increased risk of developing allergic rhinitis (OR=1.24) [R].

Individuals carrying the AA genotype had a significantly decreased risk of gastric cancer (GC) (OR=0.37, P=0.001), compared with the GG genotype [R].

Significantly increased frequencies of the GG genotype and the ''G'' allele were observed in patients with type 2 diabetes 


Parent Gene: TLR4

Importance: 2
Less common allele: A = 40%
More common allele: G = 60%
My Genotype: Log In