Women with the TT genotype had a lower bone mineral density (BMD) at the femoral neck (FN) and at the lumbar spine (LS) sites and an increased risk of osteopenia/osteoporosis in postmenopausal women [R1, R2].
The TT genotype was associated with an increased risk for non-Hodgkin lymphoma (NHL) (OR = 1.4; p for linear trend = 0.00009), diffuse large B-cell lymphoma (OR = 1.6; p for linear trend = 0.002) and follicular lymphoma (OR = 1.6; p for linear trend = 0.001) [R].
The frequency of the minor allele ''T'' was significantly higher in Crohn's disease (CD) patients than in controls [p = 0.002; OR = 1.19) [R].
A higher frequency of the TT homozygote was seen in patients with giant cell arteritis (GCA) compared to healthy controls (p = 0.05, OR 1.54). Also, a marginally significant increased frequency of the minor allele ''T'' was observed in patients with GCA who had visual ischemic manifestations (36.9%) compared to those without visual ischemic manifestations (27.7%; p = 0.04, OR 1.53). In this regard, patients with GCA carrying the minor allele ''T'' (either TT or TC) experienced visual ischemic manifestations more commonly than those carrying the CC genotype (58.5% vs 44.2%; p = 0.04, OR 1.78) [R].
A significantly increased frequency of the homozygous TT genotype was seen in Behçet's disease (BD) patients as compared with the controls (P = 0.006, odds ratio (OR) = 1.98, OR = 1.73) [R].
The frequency of the ''C'' allele was significantly higher among acute coronary syndrome (ACS) patients compared with controls (60.3% vs. 49.4%, odds ratio=1.554, p<0.05) [R].
T-cell and CD4+ cell counts in the bronchoalveolar lavage fluid were significantly higher in the TT genotype group than in the CC and CT genotype group in patients with sarcoidosis [R].
''C'' allele was associated with an overall increased risk of atherosclerosis (OR = 1.631). However, a protective role was found for ''C'' allele in ischemic stroke (IS) under recessive model and additive model with reduced heterogeneity [R].
A significantly higher frequencies of CC genotype and the ''C'' allele was found in patients with genital ulcers (p < 0.05 for both, OR 2.30 and OR 1.78 respectively) [R].