C/T alleles, are over-transmitted to affected autism spectrum disorder (ADS) individuals both singly and as a haplotype (p = .00000035) [R].

A significant preferential transmission of ''C'' allele was seen from the parents with autism to affected offspring (P = 0.006) in an Indian population. Gender-based investigations showed significant transmission of ''C'' allele to the affected females (P = 0.0025). A maternal overtransmission for these alleles was also noted [R].




Parent Gene: EN2

Importance: 2
Less common allele: T = 24%
More common allele: C = 76%
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