rs1805502 is a SNP of the GRIN2B gene. It is significantly associated with mental disorders.
There was a significant association between the ''G'' allele and treatment-resistant depression (TRD) with an excess of this allele in the TRD group, compared to non-TRD group (OR = 1.55, corrected P = 0.008) [R].
The minor allele ''G'' was associated with a significant lower reasoning ability in schizophrenia. In the postmortem brain, the ''G'' allele was associated with reduced expression of NR1 mRNA and protein in schizophrenia [R].