rs1805502 is a SNP of the GRIN2B gene. It is significantly associated with mental disorders.

There was a significant association between the ''G'' allele and treatment-resistant depression (TRD) with an excess of this allele in the TRD group, compared to non-TRD group (OR = 1.55, corrected P = 0.008) [R].

The minor allele ''G'' was associated with a significant lower reasoning ability in schizophrenia. In the postmortem brain, the ''G'' allele was associated with reduced expression of NR1 mRNA and protein in schizophrenia [R].



Parent Gene: GRIN2B

Importance: 2
Less common allele: G = 28%
More common allele: A = 72%
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