The Minor "G" allele is associated with: 

  • Each G = higher activity levels in the evening
  • Each G allele= delayed sleep onset in bipolar (mean 79 min later) and reduced amount of sleep during the night (mean 75 min less).
  • lower motility, lower HR, lower diastolic BP, and higher ghrelin.
  • delayed breakfast time
  • greater difficulty in losing weight on Mediterranean diet.

The Major "A" allele is associated with: 

  •  A = increased ADHD risk


Parent Gene: CLOCK

Importance: 4
Less common allele: G = 23%
More common allele: A = 77%
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