The A (minor) allele is associated with:
- Increased risk of developing Alzheimer’s disease in AA (R) (R).
- Possible increased risk of developing Type II diabetes (R).
- Increased risk of cardiovascular disease in patients with low HDL-cholesterol and high triglycerides (R).
Increased risk of ischemic stroke due to atherothrombotic cerebral infractions, resulting in blockage of blood vessels to the brain (R).