• The SNP is located in the promoter of the ABCA1 gene (R).

The A (minor) allele is associated with:

  • Increased risk of developing Alzheimer’s disease in AA (R) (R).
  • Possible increased risk of developing Type II diabetes (R).
  • Increased risk of cardiovascular disease in patients with low HDL-cholesterol and high triglycerides (R).
  • Increased risk of ischemic stroke due to atherothrombotic cerebral infractions, resulting in blockage of blood vessels to the brain (R).


Parent Gene: ABCA1

Importance: 3
Less common allele: A = 36%
More common allele: G = 64%
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