Although somewhat lacking in statistical power, several reports have linked rs1800947, a synonymous mutation known as CRP2 in the C-reactive protein CRP to the autoimmune disorder SLE, systemic lupus erythematosus. The risk allele in dbSNP orientation is (C). [PMID 14645206, PMID 15897982, PMID 18216863]

news C linked to lower CRP levels

[PMID 19040303] C-reactive protein gene polymorphisms in biopsy-proven giant cell arteritis from Northwestern Spain

[PMID 19426506] C-Reactive protein gene variants are associated with postoperative C-reactive protein levels after coronary artery bypass surgery

[PMID 19436291] C-reactive protein haplotype is associated with high PSA as a marker of metastatic prostate cancer but not with overall cancer risk

[PMID 19101671] Association between C-reactive protein gene haplotypes and C-reactive protein levels in Taiwanese: interaction with obesity

[PMID 19692124] Complement Factor H Y402H and C-Reactive Protein Polymorphism and Photodynamic Therapy Response in Age-Related Macular Degeneration

[PMID 19821022] Genetic variants associated with altered plasma levels of C-reactive protein are not associated with late-life cognitive ability in four Scottish samples

[PMID 20552244] Genetic polymorphism of the C-reactive protein (CRP) gene and a deep infection focus determine maximal serum CRP level in Staphylococcus aureus bacteremia

[PMID 20733302] Genetic Variants in the C-Reactive Protein Gene Are Associated with Microangiopathic Ischemic Stroke

[PMID 20333461] Serum CRP and IL-6, genetic variants and risk of colorectal adenoma in a multiethnic population

[PMID 20949557] Genetic variation in C-reactive protein (CRP) in relation to colon and rectal cancer risk and survival

[PMID 21293934] Association of C-reactive Protein Gene Polymorphisms and Colorectal Cancer

[PMID 21413847] Polymorphism in the C-reactive protein (CRP) gene affects CRP levels in plasma and one early marker of atherosclerosis in men: The Health 2000 Survey

[PMID 21080913] The CRP genotype, serum levels and lung function in men: the Caerphilly Prospective Study

[PMID 16519819] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

[PMID 16550411] Allelic spectrum of the natural variation in CRP.

[PMID 16723442] A prospective assessment of the Y402H variant in complement factor H, genetic variants in C-reactive protein, and risk of age-related macular degeneration.

[PMID 16733231] Association study between C-reactive protein genes and ischemic stroke in Japanese subjects.

[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16832152] Polymorphism of the C-reactive protein (CRP) gene is related to serum CRP Level and arterial pulse wave velocity in healthy elderly Japanese.

[PMID 17355643] Frequencies of single nucleotide polymorphisms in genes regulating inflammatory responses in a community-based population.

[PMID 17888441] Common variants in the CRP gene in relation to longevity and cause-specific mortality in older adults: the Cardiovascular Health Study.

[PMID 17900590] C-reactive protein gene variation and type 2 diabetes mellitus: a case-control study.

[PMID 17956875] DNA variants, plasma levels and variability of C-reactive protein in myocardial infarction survivors: results from the AIRGENE study.

[PMID 18000615] Common haplotypes of the C-reactive protein gene and circulating leptin levels influence the interindividual variability in serum C-reactive protein levels. The Segovia study.

[PMID 18167554] C-reactive protein (CRP) gene polymorphisms, CRP levels, and risk of incident coronary heart disease in two nested case-control studies.

[PMID 18394581] Bayesian meta-analysis of genetic association studies with different sets of markers.

[PMID 18426996] Relations of inflammatory biomarkers and common genetic variants with arterial stiffness and wave reflection.

[PMID 18439548] Loci related to metabolic-syndrome pathways including LEPR,HNF1A, IL6R, and GCKR associate with plasma C-reactive protein: the Women's Genome Health Study.

[PMID 18499652] C-reactive protein genotypes associated with circulating C-reactive protein but not with angiographic coronary artery disease: the LURIC study.

[PMID 18500540] Fine-mapping the genetic basis of CRP regulation in African Americans: a Bayesian approach.

[PMID 18704199] Comprehensive analysis of CRP, CFH Y402H and environmental risk factors on risk of neovascular age-related macular degeneration.

[PMID 18793001] Genetic variation in C-reactive protein (CRP) gene may be associated with risk of systemic lupus erythematosus and CRP concentrations.

[PMID 18974842] Gender differences in genetic risk profiles for cardiovascular disease.

[PMID 19060910] Genome-wide association analysis of metabolic traits in a birth cohort from a founder population.

[PMID 19075099] Association between C-reactive protein genotype, circulating levels, and aortic pulse wave velocity.

[PMID 19076828] Genetics of C-reactive protein and complement factor H have an epistatic effect on carotid artery compliance: the Cardiovascular Risk in Young Finns Study.

[PMID 19095725] Relation of genetic variation in the gene coding for C-reactive protein with its plasma protein concentrations: findings from the Women's Health Initiative Observational Cohort.

[PMID 19267250] C-reactive protein, interleukin-6, and prostate cancer risk in men aged 65 years and older.

[PMID 19272152] IL6 and CRP haplotypes are associated with COPD risk and systemic inflammation: a case-control study.

[PMID 19410251] Association of C-reactive protein (CRP) gene allelic variants with serum CRP levels and hypertension in Turkish adults.

[PMID 19762396] Factors associated with arterial vascular events in PROFILE: a Multiethnic Lupus Cohort.

[PMID 19796676] Polymorphisms in the CRP gene moderate an association between depressive symptoms and circulating levels of C-reactive protein.

[PMID 19906786] Unraveling the directional link between adiposity and inflammation: a bidirectional Mendelian randomization approach.

[PMID 20616999] Usefulness of Mendelian randomization in observational epidemiology.

[PMID 21034294] C-reactive protein polymorphisms are associated with the cortisol awakening response in basal conditions in human subjects.

[PMID 21325005] Association between C reactive protein and coronary heart disease: mendelian randomisation analysis based on individual participant data.

[PMID 21647738] Genome-wide association with C-reactive protein levels in CLHNS: evidence for the CRP and HNF1A loci and their interaction with exposure to a pathogenic environment.

[PMID 21773944] Lack of association between the genetic variations in the C-reactive protein gene and the risk of psoriasis among the Taiwanese.

[PMID 21790705] The polymorphisms of C-reactive protein gene modify the association between central obesity and lung function in taiwan asthmatics.

[PMID 21979869] C-reactive protein haplotypes and dispositional optimism in obese and nonobese elderly subjects.

[PMID 23254959] Serum C-reactive protein and risk of lung cancer: a case-control study

[PMID 23397258] Association study of CRP gene in systemic sclerosis in European Caucasian population.

[PMID 24844401] Genetic variation across C-reactive protein and risk of prostate cancer

[PMID 24862635] Association of CRP gene polymorphisms with serum CRP level and handgrip strength in community-dwelling elders in Taiwan: Taichung Community Health Study for Elders (TCHS-E)

[PMID 24894103] Serum C-reactive protein level but not its gene polymorphism is associated with Takayasu arteritis

[PMID 24761881] Genotype CC of rs1800947 in the C-reactive protein gene may increase susceptibility to colorectal cancer: a meta-analysis

[PMID 25043606] Association of CRP genetic variants with blood concentrations of C-reactive protein and colorectal cancer risk

[PMID 26004291] C-reactive protein gene polymorphisms and gene-environment interactions in ischaemic stroke

[PMID 26550110] The role of gene variants of the inflammatory markers CRP and TNF-Πin cardiovascular heart disease: systematic review and meta-analysis


Parent Gene: CRP

Importance: 1
Less common allele: G = 3%
More common allele: C = 97%
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