asthma related [PMID 17561245]

This SNP is in the promoter region of the IL-13 gene

PMID: 17615386 IL-13 is involved in pulmonary inflammation, remodeling and susceptibility to chronic obstructive pulmonary disease (COPD). This IL13 promoter polymorphism may modulate the adverse effects of cigarette smoking on pulmonary function in long-term cigarette smokers. Every 20 pack-year increment in smoking was associated with a 2.4% reduction in mean ppFEV1(forced expiratory volume in 1 second, a measure used to assess lung disease, like COPD) in the common homozygous (CC) or heterozygous (CT) promoter genotypes, and an 8.2% reduction in mean ppFEV1 in minor allele homozygotes (TT, recessive model).

  • pack-year= packs per day x years smoked

[PMID 18614543] rs1800925 and/or rs11568506 related to psoriasis and/or Crohn's disease ?

[PMID 18273035] rs324013 and rs1800925 influence transcription factor binding. These results are consistent with the Th2 cytokine pathway enhancing resistance to schistosome infection.

[PMID 19254294] Contribution of functional variation in the IL13 gene to allergy, hay fever and asthma in the NSHD longitudinal 1946 birth cohort.

[PMID 19471606] Recent advances in the characterization of genetic factors involved in human susceptibility to infection by schistosomiasis

[PMID 19515749] Favorable impact of the interleukin-4 receptor allelic variant I75 on the survival of diffuse large B-cell lymphoma patients demonstrated in a large prospective clinical trial

[PMID 19796199] Polymorphisms in IL13 pathway genes in asthma and chronic obstructive pulmonary disease [PMID 19840389] Identification of a haplotype block in the 5q31 cytokine gene cluster associated with the susceptibility to severe malaria

[PMID 20403202] Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: a prospective birth cohort study

[PMID 19968631] Gene-gene and gene-environment interactions on IgE production in prenatal stage

[PMID 20975284] Case-Control Study of Eczema Associated with IL13 Genetic Polymorphisms in Japanese Children

[PMID 21050946] Does genetic regulation of IgE begin in utero? Evidence from T(H)1/T(H)2 gene polymorphisms and cord blood total IgE

[PMID 20484924] Interleukin 13 and interleukin 4 receptor-? polymorphisms in rhinitis and asthma

[PMID 21309855] A meta-analysis of Th2 pathway genetic variants and risk for allergic rhinitis

[PMID 22013915] IL13 genetic polymorphisms, smoking, and eczema in women: a case-control study in Japan

[PMID 22023794] Case-control study of IL13 polymorphisms, smoking, and rhinoconjunctivitis in Japanese women: the Kyushu Okinawa Maternal and Child Health Study

[PMID 22053598] Association of TGF-beta1, IL-4 and IL-13 gene polymerphisms with asthma in a Chinese population

[PMID 22432974] Environmental tobacco smoke and male sex modify the influence of IL-13 genetic variants on cord blood IgE levels

[PMID 22750299] Association of interleukin-13 SNP rs1800925 with allergic rhinitis risk: A meta-analysis based on 1,411 cases and 3,169 controls

[PMID 15660293] No evidence of association or interaction between the IL4RA, IL4, and IL13 genes in type 1 diabetes.

[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16024651] Polymorphisms associated with asthma are inversely related to glioblastoma multiforme.

[PMID 16091150] Characterization of the linkage disequilibrium structure and identification of tagging-SNPs in five DNA repair genes.

[PMID 16449530] Cytokine polymorphisms in the Th1/Th2 pathway and susceptibility to non-Hodgkin lymphoma.

[PMID 16832637] Evaluation of interleukin 13 polymorphisms in systemic sclerosis.

[PMID 17142763] Th2 cell-selective enhancement of human IL13 transcription by IL13-1112C>T, a polymorphism associated with allergic inflammation.

[PMID 17303794] Ethnicity-specific gene-gene interaction between IL-13 and IL-4Ralpha among African Americans with asthma.

[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17346294] IL13 gene polymorphism association with cord serum immunoglobulin E.

[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 18006935] An international case-control study of interleukin-4Ralpha, interleukin-13, and cyclooxygenase-2 polymorphisms and glioblastoma risk.

[PMID 18037162] Patterns of GATA3 and IL13 gene polymorphisms associated with childhood rhinitis and atopy in a birth cohort.

[PMID 18056382] Analysis of the 5q31 33 locus shows an association between single nucleotide polymorphism variants in the IL-5 gene and symptomatic infection with the human blood fluke, Schistosoma japonicum.

[PMID 18075513] Variants in the 5q31 cytokine gene cluster are associated with psoriasis.

[PMID 18186920] IL13 gene polymorphisms modify the effect of exposure to tobacco smoke on persistent wheeze and asthma in childhood, a longitudinal study.

[PMID 18410415] Polymorphisms in the interleukin 13 and GATA binding protein 3 genes and the development of eczema during childhood.

[PMID 18625055] Lack of association or interactions between the IL-4, IL-4Ralpha and IL-13 genes, and rheumatoid arthritis.

[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 18687755] Genetic variants in T helper cell type 1, 2 and 3 pathways and gastric cancer risk in a Polish population.

[PMID 18846228] Genome-wide scan on total serum IgE levels identifies FCER1A as novel susceptibility locus.

[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19356949] Cytokine SNPs: Comparison of allele frequencies by race and implications for future studies.

[PMID 19554022] Association between IL13 polymorphisms and psoriatic arthritis is modified by smoking.

[PMID 19759553] Genetic and environmental risk factors for childhood eczema development and allergic sensitization in the CCAAPS cohort.

[PMID 19956101] Overview of the Rapid Response data.

[PMID 19956109] The Type I Diabetes Genetics Consortium 'Rapid Response' family-based candidate gene study: strategy, genes selection, and main outcome.

[PMID 20015396] Innate immunity in ocular Chlamydia trachomatis infection: contribution of IL8 and CSF2 gene variants to risk of trachomatous scarring in Gambians.

[PMID 20358028] IL-13 Gene Polymorphisms are Associated With Rhinosinusitis and Eosinophilic Inflammation in Aspirin Intolerant Asthma.

[PMID 20418110] Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer .

[PMID 20444268] Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets.

[PMID 20606885] Genetics of psoriasis and psoriatic arthritis.

[PMID 20644561] A large-scale candidate gene approach identifies SNPs in SOD2 and IL13 as predictive markers of response to preoperative chemoradiation in rectal cancer.

[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 20861864] Association of rs7719175, located in the IL13 gene promoter, with Schistosoma haematobium infection levels and identification of a susceptibility haplotype.

[PMID 21071541] Risk of cervical cancer associated with allergies and polymorphisms in genes in the chromosome 5 cytokine cluster.

[PMID 21320344] Evaluation of genetic susceptibility to childhood allergy and asthma in an African American urban population.

[PMID 21349879] Evidence to support IL-13 as a risk locus for psoriatic arthritis but not psoriasis vulgaris.

[PMID 21613309] IL13 gene polymorphism is a marker for psoriatic arthritis among psoriasis patients.

[PMID 21649724] Variation in human genetic polymorphisms, their association with Helicobacter pylori acquisition and gastric cancer in a multi-ethnic country.

[PMID 22045834] Polymorphisms in the interleukin 4, interleukin 13, and corresponding receptor genes are not associated with systemic sclerosis and do not influence gene expression.

[PMID 22222605] IL-13 polymorphisms contribute to the risk of asthma: a meta-analysis.

[PMID 23668806] Association of IL-4 and IL-10 maternal haplotypes with immune responses to P. falciparum in mothers and newborns

[PMID 23299779] Interleukin-10 gene polymorphisms are associated with freedom from treatment failure for patients with Hodgkin lymphoma

[PMID 23886125] Interleukin 10 rs1800872 T>G Polymorphism was Associated with an Increased Risk of Esophageal Cancer in a Chinese Population

[PMID 24286397] Association between the interleukin-13 gene and development of chronic obstructive pulmonary disease in southern Chinese Han population: a case-control study

[PMID 23246181] Association between IL13 gene polymorphisms and susceptibility to cancer: a meta-analysis.

[PMID 23549736] Association of the SNP rs1800925(C/T) in the interleukin-13 gene promoter with pulmonary function in Chinese Han patients with idiopathic pulmonary fibrosis.

[PMID 25658755] Association between Polymorphism of the Interleukin-13 Gene and Susceptibility to Hepatocellular Carcinoma in the Chinese Population

[PMID 26258681] An IL-13 Promoter Polymorphism Associated with Liver Fibrosis in Patients with Schistosoma japonicum

[PMID 26365633] Lack of association between RAD50-IL13 polymorphisms and pediatric asthma susceptibility in Northeastern Han Chinese

[PMID 26387812] Association of single nucleotide polymorphisms in IL8 and IL13 with sunitinib-induced toxicity in patients with metastatic renal cell carcinoma


Parent Gene: IL13

Importance: 1
Less common allele: T = 26%
More common allele: C = 74%
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