rs1800587, also known as C-889T, is a SNP in the IL-1 alpha IL1A gene.

A study of 556 adults in the Western Australian coronary heart disease (CHD) population concluded that rs1800587(T;T) homozygotes had larger waist circumference, by 1.8cm on average, compared to major allele (C;C) homozygotes. This association was even more pronounced in patients with higher levels of obesity or inflammatory markers. [PMID 18716798]

rs1800587 increases susceptibility to Intervertebral disc disease 1.31 times for (C;T) heterozygotes and 7.87 times for (T;T) homozygotes [PMID 17471097]

This SNP has also been reported to be associated with Alzheimer's disease in a few studies, but probably ruled out in even more studies, such as this one [PMID 19158434].


[PMID 19619703] Association of genetic variants with the metabolic syndrome in 20,806 white women: The women's health genome study


[PMID 20157068] Association of IL1A, IL1B, and TNF Gene Polymorphisms With Chronic Rhinosinusitis With and Without Nasal Polyposis: A Replication Study


[PMID 20565898] Association of IL1A and IL1B loci with primary open angle glaucoma

[PMID 20116409] The association of interleukin-1alpha and interleukin-1beta polymorphisms with the risk of Graves' disease in a case-control study and meta-analysis

[PMID 21070631] The dopamine beta-hydroxylase -1021C/T polymorphism is associated with the risk of Alzheimer's disease in the Epistasis Project


[PMID 21637534] Interleukin-8-251T > A, Interleukin-1?-889C > T and Apolipoprotein E polymorphisms in Alzheimer's disease


[PMID 22216303] Functional Polymorphism of IL-1 Alpha and Its Potential Role in Obesity in Humans and Mice


[PMID 21672595] Single nucleotide polymorphisms in interleukin-1gene cluster and subgingival colonization with Aggregatibacter actinomycetemcomitans in patients with aggressive periodontitis


[PMID 22285486] Association of IL1R polymorphism with HLA-B27 positive in Iranian patients with ankylosing spondylitis


[PMID 21509504] Interleukin-1α, interleukin-1β and tumor necrosis factor-α genetic variants and risk of dementia in the very old: evidence from the "Monzino 80-plus" prospective study

[PMID 15726497] Gene-environment interaction effects on the development of immune responses in the 1st year of life.

[PMID 16078996] Association study of functional genetic variants of innate immunity related genes in celiac disease.

[PMID 16519819] Analysis of polymorphisms in 16 genes in type 1 diabetes that have been associated with other immune-mediated diseases.

[PMID 16617143] Algorithm for automatic genotype calling of single nucleotide polymorphisms using the full course of TaqMan real-time data.

[PMID 16719905] Association study of genetic variants of pro-inflammatory chemokine and cytokine genes in systemic lupus erythematosus.

[PMID 16820586] Inflammatory gene polymorphisms and risk of postoperative myocardial infarction after cardiac surgery.

[PMID 16916584] Interleukin-1 alpha and beta, TNF-alpha and HTTLPR gene variants study on alcohol toxicity and detoxification outcome.

[PMID 17205326] The effect of interleukin-1alpha polymorphisms on bone mineral density and the risk of vertebral fractures.

[PMID 17327408] Prognostic significance of host immune gene polymorphisms in follicular lymphoma survival.

[PMID 17459217] [A meta-analysis on interleukin-1 gene cluster polymorphism and genetic susceptibility for ankylosing spondylitis].

[PMID 17705862] Optimization of candidate-gene SNP-genotyping by flexible oligonucleotide microarrays; analyzing variations in immune regulator genes of hay-fever samples.

[PMID 18576312] A broad analysis of IL1 polymorphism and rheumatoid arthritis.

[PMID 18603647] Functional genetic polymorphisms and female reproductive disorders: Part I: Polycystic ovary syndrome and ovarian response.

[PMID 18633131] Host immune gene polymorphisms in combination with clinical and demographic factors predict late survival in diffuse large B-cell lymphoma patients in the pre-rituximab era.

[PMID 18676870] Variants in inflammation genes and the risk of biliary tract cancers and stones: a population-based study in China.

[PMID 19035492] Cytokine gene polymorphisms as risk and severity factors for juvenile dermatomyositis.

[PMID 19043479] Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients.

[PMID 19066394] Organochlorine exposure, immune gene variation, and risk of non-Hodgkin lymphoma.

[PMID 19131662] A meta-analysis of candidate gene polymorphisms and ischemic stroke in 6 study populations: association of lymphotoxin-alpha in nonhypertensive patients.

[PMID 19155622] Interleukin-1alpha -889 C/T polymorphism in Turkish patients with late-onset Alzheimer's disease.

[PMID 19263529] Genetic risk factors in recurrent venous thromboembolism: A multilocus, population-based, prospective approach.

[PMID 19330901] Association of 77 polymorphisms in 52 candidate genes with blood pressure progression and incident hypertension: the Women's Genome Health Study.

[PMID 19559392] A candidate gene association study of 77 polymorphisms in migraine.

[PMID 19742166] Epistasis between IL1A, IL1B, TNF, HTR2A, 5-HTTLPR and TPH2 variations does not impact alcohol dependence disorder features.

[PMID 20031567] An evaluation of candidate genes of inflammation and thrombosis in relation to the risk of venous thromboembolism: The Women's Genome Health Study.

[PMID 20192980] The interleukin-1 cluster gene region is associated with multiple sclerosis in an Italian Caucasian population.

[PMID 20196868] Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis.

[PMID 20347268] Convergent evidence shows a positive association of interleukin-1 gene complex locus with susceptibility to schizophrenia in the Caucasian population.

[PMID 20353565] Allelic variants of IL1R1 gene associate with severe hand osteoarthritis.

[PMID 20574532] Intermediate phenotypes identify divergent pathways to Alzheimer's disease.

[PMID 20811626] Genetic variants in inflammation-related genes are associated with radiation-induced toxicity following treatment for non-small cell lung cancer.

[PMID 20934174] Association of IL1 gene polymorphisms with chronic periodontitis in Brazilians.

[PMID 21205020] Associations between interleukin-1 (IL-1) gene variations or IL-1 receptor antagonist levels and the development of type 2 diabetes.

[PMID 21385326] Association of interleukin-1 gene polymorphisms with sudden sensorineural hearing loss and Meniere's disease.

[PMID 22035161] Postorthodontic external root resorption is associated with IL1 receptor antagonist gene variations.

[PMID 22341060] Postorthodontic external root resorption in root-filled teeth is influenced by interleukin-1beta polymorphism.


[PMID 23050050] Gender difference in genetic association between IL1A variant and early lumbar disc degeneration: a three-year follow-up


[PMID 22723975] Polymorphisms in RYBP and AOAH genes are associated with chronic rhinosinusitis in a Chinese population: a replication study


[PMID 23216199] Associations of the interleukin-1 gene locus polymorphisms with risk to hip and knee osteoarthritis: gender and subpopulation differences


[PMID 24103372] Interleukin-1 alpha (rs1800587) genetic polymorphism is associated with specific cognitive functions but not depression or loneliness in elderly males without dementia


[PMID 24357513] The variant interleukin 1f7 rs3811047 G>A was associated with a decreased risk of gastric cardiac adenocarcinoma in a Chinese Han population


[PMID 24460370] Relationship Between IL1 Gene Polymorphisms and Periodontal Disease in Japanese Women


[PMID 24477584] Genetic association of IDE, POU2F1, PON1, IL1α and IL1β with type 2 diabetes in Pakistani population


[PMID 21962386] The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis.


[PMID 22623017] Serotonin transporter-linked polymorphic region (5-HTTLPR) genotype is associated with cortisol responsivity to naloxone challenge.


[PMID 22925444] Genetic and immunological markers predict titanium implant failure: a retrospective study.


[PMID 23459936] Exploring the genetic basis of chronic periodontitis: a genome-wide association study.


[PMID 23594042] Multiple sclerosis: association with the interleukin-1 gene family polymorphisms in the Turkish population.


[PMID 23722873] Interleukin-1 gene cluster and IL-1 receptor polymorphisms in Iranian patients with systemic lupus erythematosus.


[PMID 25446437] Association of IL-1, IL-18, and IL-33 gene polymorphisms with late-onset Alzheimer׳s disease in a Hunan Han Chinese population


[PMID 25758360] Saving more teeth-a case for personalized care


[PMID 25865535] Genetic and treatment-related risk factors associated with external apical root resorption (EARR) concurrent with orthodontia


[PMID 25902400] Polymorphisms in the inflammatory pathway genes and the risk of preeclampsia in Sinhalese women


[PMID 26578206] Genetic Associations of Interleukin-related Genes with Graves' Ophthalmopathy: a Systematic Review and Meta-analysis

rs1800587

Parent Gene: IL1A

Importance: 1
Less common allele: A = 28%
More common allele: G = 72%
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