Mechanism:

  • The A (minor) version causes a change in the protein sequence of NQO1 that results in the protein being destroyed by cells.
  • The A allele (especially AA) has been shown to cause NQO1 to have a lower activity and stability (R).
  • Having the AA genotype leaves cells completely devoid of NQO1 protein (R).

The Minor "A" allele is associated with:

  • Lower levels of NQO1 protein.
  • More oxidative stress.
  • According to the study 4% of people of European descent and up to 20% of the Asian population have the AA genotype (R).
  • Laboratory tests found that cancer cells with the AA genotype were not as efficiently killed by epirubicin *chemotherapy drug) as cells that do contain the protein. The study showed that the effectiveness of other types of cancer treatment, including radiation and other drugs, were not affected by the rs1800566 genotype or the amount of NQO1 present (R).

rs1800566

Parent Gene: NQO1

Importance: 5
Less common allele: A = 29%
More common allele: G = 71%
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