rs1799998 is a SNP of the CYP11B2 gene. It may contribute to the risk of ischemic stroke (IS) with a moderate effect [R].
G/A genotype may contribute to the risk of ischemic stroke (IS) (P(dominant)=0.003, P(additive)=0.003, respectively) [R].
Subjects who carried the ''G'' allele were significantly associated with coronary heart disease and severity of coronary atherosclerosis estimated by the Gensini score. Compared to the subjects with AA genotype, the subjects with AG + GG genotype had significant lower gensini score (p=0.029) [R].
A significant association of G/A genotype was seen with all subtypes of chronic glomerulonephritis (GN) (OR = 1.925, p = 0.0118, p(corr) = 0.0354)) [R].
The presence of the AA genotype was associated with an increased risk of 1.98-fold for recurrent cerebral ischemia (the hazard ratio 1.98, p=0.01) [R].