rs1799990 is a SNP in the prion protein PRNP gene. Since 1991 this SNP has been significantly associated with the risk of Creutzfeldt–Jakob disease (CJD) [R].

All the patients with variant Creutzfeldt–Jakob disease (vCJD) were homozygous for the ''A'' allele indicating that the homozygous genotypes were at an increased risk relative to heterozygous groups [R1, R2].



Parent Gene: PRNP

Importance: 2
Less common allele: G = 27%
More common allele: A = 73%
My Genotype: Log In
Risk Allele: A

Disease/Trait: Creutzfeldt Jacob Disease

The A allele of rs1799990 is reported to be associated with Creutzfeldt Jacob Disease (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Creutzfeldt-Jakob disease.

Disease/Trait: Prion Disease

rs1799990 is associated with Prion Disease (R) . It is reported to increased association with Prion diseases. No specific risk allele was identified in the study.