The Minor "C" allele is associated with:

  • Strengthened correlation between poor sleep patterns and weight gain, based on a  longterm study of children ages 5-11 [R].

The Major "T" allele is associated with:

  • Caffeine-induced anxiety with ingestion of more than 150 mg of caffeine for individuals with the both the (T,T)  genotype and the (C,C) genotype at secondary gene location ADORA2A rs2298383 [R].

  • Better response in Schizophrenic patients to the antipsychotic drug Risperidone [R] This may be isolated to patients of Asian heritage [R].

  • Psychological resilience. In a single study of 805 urban individuals having experienced a past trauma, those with the (T,T) genotype were significantly less likely to have post-traumatic stress disorder [R].

The "T" allele as part of a haplotype is associated with:

  • Increased risk for opiate addiction, based on a study of Methadone substituted patients  [R]. This risk is dependent upon the simultaneous presence of alleles A,G,A at  the locations DRD2 rs1076560, rs6277, and ANKK1 rs 1800497, respectively. [R]

This SNP is associated with (unknown  which alleles):

  • A weak correlation to Alcohol dependence and withdrawal, based on a study of 262 families showing alcoholism [R].


Parent Gene: DRD2

Importance: 3
Less common allele: C = 12%
More common allele: T = 88%
My Genotype: Log In