rs1799941 is a SNP of the SHBG gene. It is significantly associated with sex-hormone binding globulin (SHBG) levels as well as sex hormone regulation.

''A'' allele was associated with increasing testosterone levels in men (P= 8.11 × 10−6) [R].

Subjects with the ''A'' allele (GA+AA) had a trend for lower free estradiol index (FEI) compared to the GG genotype (p=0.04) [R].

Each copy of the ''A'' allele is associated with a 0.20 SDs increase in sex hormone binding globulin (SHBG) levels [R].

Carriers of the minor allele ''A'' had higher circulating SHBG, independently of sex, age, and total body fat (P = 0.025) [R1, R2].

 

rs1799941

Parent Gene: SHBG

Importance: 2
Less common allele: A = 10%
More common allele: G = 90%
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