rs1799884 is a SNP of the GCK gene. It is significantly associated with an increased risk of Type 2 diabetes (T2D).

The ''T'' allele was significantly associated with decreased HOMA-B (homeostatic model assesment) (p= 0.0005), but not with type 2 diabetes or impaired fasting glucose (IFG) [R].

A maternal ''T'' allele was associated with a 32-g increase in offspring birth weight (P=.002) [R].

''T'' allele was associated with higherfasting plasma glucose (FPG) (P = 3.1 x 10(-7)) in adults and adolescents [R].

''T'' allele was also associated with reduced homeostasis model assessment of beta-cell function (HOMA-B) (P=0.0015) [R].

Minor allele ''T'' was significantly associated with a higher risk of gestational diabetes mellitus (GDM) [R].

rs1799884

Parent Gene: GCK, YKT6

Importance: 5
Less common allele: T = 17%
More common allele: C = 83%
My Genotype: Log In
Risk Allele: A, T, T, T, A, A, A

Disease/Trait: Fasting Blood Glucose Measurement

The A allele of rs1799884 is reported to be associated with Fasting Blood Glucose Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Metabolite levels (FPG).

Disease/Trait: A1c Measurement

The T allele of rs1799884 is reported to be associated with A1c Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycated hemoglobin levels.

Disease/Trait: A1c Measurement

The T allele of rs1799884 is reported to be associated with A1c Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycated hemoglobin levels (HbA1c).

Disease/Trait: A1c Measurement

The T allele of rs1799884 is reported to be associated with A1c Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycated hemoglobin levels.

Disease/Trait: Type Ii Diabetes Mellitus

The A allele of rs1799884 is reported to be associated with Type Ii Diabetes Mellitus (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycemic traits (FPG).

Disease/Trait: Type Ii Diabetes Mellitus

The A allele of rs1799884 is reported to be associated with Type Ii Diabetes Mellitus (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycemic traits (1-hPG).

Disease/Trait: Type Ii Diabetes Mellitus

The A allele of rs1799884 is reported to be associated with Type Ii Diabetes Mellitus (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycemic traits (2-hPG).