The Minor "T" allele is associated with:

  • Needs a higher dose of warfarin (TT) (R).
  • CYP2C9*2 poor metabolizer; 40% reduction in Warfarin metabolism (TT)

The Major "C" allele is associated with:

  • One CYP2C9*2 allele, reduced activity of CYP2C9 (CT)
  • Normal Poor metabolizer of THC, ibuprofen, sildenafil (viagra), fluoxetine, losartan, phenytoin, limonene, ketamine. (CC)

Will inhibit CYP2C9:Flavanols, Flavones, Quercetin, Garlic,Pomegranate, Hops, Saw Palmetto, Milk Thistle, Apigenin(potent), Cranberry, Chamomile, Goji, St John's Wort, Ginko, Fluconazole, Baicalein (R), Fluconazole, Valproic acid,

Will induce CYP2C9:Limonene,Melatonin,Quercetin
 

rs1799853

Parent Gene: CYP2C9

Importance: 5
Less common allele: T = 5%
More common allele: C = 95%
My Genotype: Log In
Risk Allele:

Disease/Trait: Response To Anticoagulant

rs1799853 is associated with Response To Anticoagulant (R) . It is reported to have a 0.54 mg/week decrease on Warfarin maintenance dose. No specific risk allele was identified in the study.