The Minor "T" allele is associated with:
- Needs a higher dose of warfarin (TT) (R).
- CYP2C9*2 poor metabolizer; 40% reduction in Warfarin metabolism (TT)
The Major "C" allele is associated with:
- One CYP2C9*2 allele, reduced activity of CYP2C9 (CT)
- Normal Poor metabolizer of THC, ibuprofen, sildenafil (viagra), fluoxetine, losartan, phenytoin, limonene, ketamine. (CC)
Will inhibit CYP2C9:Flavanols, Flavones, Quercetin, Garlic,Pomegranate, Hops, Saw Palmetto, Milk Thistle, Apigenin(potent), Cranberry, Chamomile, Goji, St John's Wort, Ginko, Fluconazole, Baicalein (R), Fluconazole, Valproic acid,