Mechanism:

  • Normal levels of DRD2 within the body (G)
  • Unknown effect. More research needs to be performed (A)
  • can also be referred to as the -141 Ins/Del [R].

The Minor "A" allele is associated with:

  • Younger onset schizophrenia [R, R2, R3].
  • Increased weight gain in subjects taking antipsychotic medications [R].
  • Less favorable treatment outcome for schizophrenia [R].
  • Increased risk of inhaling heroin abuse [R].
  • Boys with multiple polymorphisms in the DRD2 gene demonstrate higher reward-dependence and novelty seeking [R].
  • Increased affect of Nicotine Replacement Therapy tobacco dependence drug therapy in tobacco dependent patients [R].
  • Decreased affect of bupropion tobacco dependence drug therapy in tobacco dependent patients [R].
  • Colorectal cancer [R].
  • AA= increased risk of severe alcoholism (2.0 times) II=increased risk of severe alcoholism (1.85 times) (R). (A;A) severe alcoholism 2x (I;I) severe alcoholism 1.85x (R).

The Major "G" allele is associated with:

  • Decreased affect of NRT tobacco dependence drug therapy in tobacco dependent patients [R].
  • Increased affect of bupropion tobacco dependence drug therapy in tobacco dependent patients [R].
  • More favorable treatment outcome of schizophrenia [R].
  • Decreased weight gain in subjects taking antipsychotic medications [R].
  • Adenoma recurrence in colorectal cancer [R].
  • Increased benign tumor recurrence risk [R, R2].

rs1799732

Parent Gene: DRD2

Importance: 3
Less common allele: G = 76%
More common allele: None = None
My Genotype: Log In