• SNP is also known as c.538G>A or G180R
  • SNP in the ATP-binding cassette, sub-family C (CFTR/MRP), member 11 ABCC11 gene.
  • The ABCC11 protein helps transport small molecules across apical membranes such as those in apocrine secretory cells.

The T (minor) allele is associated with:

  • Decreased Nipple aspiration fluid (NAF) yields in women. NAF can be used to non-invasively determine breast environment (R).

  • Increased dryness of earwax (R).

  • Shorter relapse-free survival times in lung cancer patients administered S-1 one year after the operation to remove the tumor (TT) (R).

  • Decreased body odor (TT) (R).

The C (major) allele is associated with:

  • Increased risk of developing breast cancer (R).  This must be studied further. 

  • Increased wetness of earwax (R).

  • Increased body odor (R).


Parent Gene: ABCC11

Importance: 4
Less common allele: T = 30%
More common allele: C = 70%
My Genotype: Log In