The Minor "C" allele is associated with:
- Increases the risk of obesity and less HPA activation.
- 2.5 adults likely to be 0.44 BMI units higher, CT= 2 adults likely to be 0.22 BMI units higher, TT= 0 adults see an increase. A study on 77,228 European adults concluded that each copy of the C-allele at this SNP correlates to a BMI increase of about 0.22 and an 8% increased risk for being overweight (CC).
- Decreased satiation of appetite, causing more frequent eating and snacking frequently on foods with higher fat content. (Greatest effect on 7-11 years old), making overeating a clear cause for weight gain associated with this gene (Loos et al., 2008).
- The effects of the C-allele on BMI have also been confirmed in Africans (Liu et al., 2011; Hester et al, 2012) and Asians (Sully et al., 2013; Xi et al., 2013).
- Reduced levels of physical activity [R]