Mechanism:

MC4R protein deficiency causes obesity and lowers HPA activation.

The Minor "C" allele is associated with:

  • Increases the risk of obesity and less HPA activation.
  • 2.5 adults likely to be 0.44 BMI units higher, CT= 2 adults likely to be 0.22 BMI units higher, TT= 0 adults see an increase. A study on 77,228 European adults concluded that each copy of the C-allele at this SNP correlates to a BMI increase of about 0.22 and an 8% increased risk for being overweight (CC).
  • Decreased satiation of appetite, causing more frequent eating and snacking frequently on foods with higher fat content. (Greatest effect on 7-11 years old), making overeating a clear cause for weight gain associated with this gene (Loos et al., 2008).
  • The effects of the C-allele on BMI have also been confirmed in Africans (Liu et al., 2011; Hester et al, 2012) and Asians (Sully et al., 2013; Xi et al., 2013).
  • Reduced levels of physical activity [R]

rs17782313

Parent Gene: MC4R

Importance: 5
Less common allele: C = 24%
More common allele: T = 76%
My Genotype: Log In
Risk Allele: C, C, T, C, C, C, T

Disease/Trait: Body Mass Index

The C allele of rs17782313 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index.

Disease/Trait: Body Mass Index

The C allele of rs17782313 is reported to be associated with Body Mass Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Body mass index.

Disease/Trait: Body Height

The T allele of rs17782313 is reported to be associated with Body Height (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Height.

Disease/Trait: Obesity

The C allele of rs17782313 is reported to be associated with Obesity (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Obesity.

Disease/Trait: Obesity

The C allele of rs17782313 is reported to be associated with Obesity (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Obesity (children).

Disease/Trait: Obesity

The C allele of rs17782313 is reported to be associated with Obesity (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Obesity (adults).

Disease/Trait: Body Height

The T allele of rs17782313 is reported to be associated with Body Height (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Height.