rs174547 lies in the FADS1 gene. It was significantly associated with fasting blood glucose (p=1.48×10⁻⁶) [R]. 

rs174547 also influenced the low-density lipoprotein cholesterol (LDL-C) concentration in males, in particular this influence was more significant in older males (P = 1.39;E-06) but not younger males (P = 0.99) [R].

The ''C'' allele was associated with lower LDL (low density lipoprotein) concentration (P = 0.03) [R].

The copy number of the ''C'' allele was significantly associated with increased triglyceride levels (P = 1.5 x 10(-6)) and decreased HDL (high density lipoprotein) -C levels (P = 0.03) in the Japanese population. On the other hand, in the Mongolian population, the ''C'' allele copy number was strongly associated with decreased LDL-C levels (P = 2.6 x 10(-6)), but was not associated with triglyceride and HDL-C levels [R].

 

 

rs174547

Parent Gene: FADS1

Importance: 5
Less common allele: C = 30%
More common allele: T = 70%
My Genotype: Log In
Risk Allele: C, C, C, C, C, T, T, C, T, T, T, T, T, T, T, T, T, T, T, C, T, T, T

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

The C allele of rs174547 is reported to be associated with High Density Lipoprotein Cholesterol Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with HDL cholesterol.

Disease/Trait: Triglyceride Measurement

The C allele of rs174547 is reported to be associated with Triglyceride Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Triglycerides.

Disease/Trait: Resting Heart Rate

The C allele of rs174547 is reported to be associated with Resting Heart Rate (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Resting heart rate.

Disease/Trait: Comprehensive Strength Index

The C allele of rs174547 is reported to be associated with Comprehensive Strength Index (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Comprehensive strength and appendicular lean mass (Males + Females).

Disease/Trait: Muscle Measurement

The C allele of rs174547 is reported to be associated with Muscle Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Comprehensive strength and appendicular lean mass (Males + Females).

Disease/Trait: Omega-6 Polyunsaturated Fatty Acid Measurement

The T allele of rs174547 is reported to be associated with Omega-6 Polyunsaturated Fatty Acid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Plasma omega-6 polyunsaturated fatty acid levels (gamma-linolenic acid).

Disease/Trait: Omega-6 Polyunsaturated Fatty Acid Measurement

The C allele of rs174547 is reported to be associated with Omega-6 Polyunsaturated Fatty Acid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Plasma omega-6 polyunsaturated fatty acid levels (arachidonic acid).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174547 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (lysoPhosphatidylcholine acyl C20:4).

Disease/Trait: Glycerophospholipid Measurement

The T allele of rs174547 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (lysoPhosphatidylcholine acyl C20:4).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174547 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C34:4).

Disease/Trait: Glycerophospholipid Measurement

The T allele of rs174547 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C34:4).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174547 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C36:4).

Disease/Trait: Glycerophospholipid Measurement

The T allele of rs174547 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C36:4).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174547 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C38:4).

Disease/Trait: Glycerophospholipid Measurement

The T allele of rs174547 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine diacyl C38:4).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174547 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine acyl-alkyl C36:4).

Disease/Trait: Glycerophospholipid Measurement

The T allele of rs174547 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine acyl-alkyl C36:4).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174547 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine acyl-alkyl C36:5).

Disease/Trait: Glycerophospholipid Measurement

The T allele of rs174547 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine acyl-alkyl C36:5).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174547 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine acyl-alkyl C38:5).

Disease/Trait: Glycerophospholipid Measurement

The T allele of rs174547 is reported to be associated with Glycerophospholipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Glycerophospholipid levels (Phosphatidylcholine acyl-alkyl C38:5).

Disease/Trait: Sphingolipid Measurement

The T allele of rs174547 is reported to be associated with Sphingolipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Sphingolipid levels (Sphingomyeline C16:1).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174547 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Sphingolipid levels (Sphingomyeline C16:1).

Disease/Trait: Sphingolipid Measurement

The T allele of rs174547 is reported to be associated with Sphingolipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Sphingolipid levels (Sphingomyeline C18:1).

Disease/Trait: Blood Metabolite Measurement

The T allele of rs174547 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Sphingolipid levels (Sphingomyeline C18:1).

Disease/Trait: Body Height

The T allele of rs174547 is reported to be associated with Body Height (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Height.

Disease/Trait: Trans Fatty Acid Measurement

The T allele of rs174547 is reported to be associated with Trans Fatty Acid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Trans fatty acid levels (Cis/trans-18:2, EA).

Disease/Trait: Cis/Trans-18:2 Fatty Acid Measurement

The T allele of rs174547 is reported to be associated with Cis/trans-18:2 Fatty Acid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Trans fatty acid levels (Cis/trans-18:2, EA).

Disease/Trait: Lipid Measurement

The C allele of rs174547 is reported to be associated with Lipid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Metabolite levels (lipid measures) (other polyunsaturated fatty acids than 18:2).

Disease/Trait: Blood Metabolite Measurement

The C allele of rs174547 is reported to be associated with Blood Metabolite Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Metabolite levels (lipid measures) (other polyunsaturated fatty acids than 18:2).

Disease/Trait: Linoleic Acid Measurement

The T allele of rs174547 is reported to be associated with Linoleic Acid Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Plasma omega-6 polyunsaturated fatty acid levels (linoleic acid).

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

rs174547 is associated with High Density Lipoprotein Cholesterol Measurement (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Triglyceride Measurement

rs174547 is associated with Triglyceride Measurement (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Body Mass Index

rs174547 is associated with Body Mass Index (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Systolic Blood Pressure

rs174547 is associated with Systolic Blood Pressure (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Diastolic Blood Pressure

rs174547 is associated with Diastolic Blood Pressure (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Total Cholesterol Measurement

rs174547 is associated with Total Cholesterol Measurement (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Glucose Measurement

rs174547 is associated with Glucose Measurement (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Hematocrit

rs174547 is associated with Hematocrit (R) . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Ventricular Rate Measurement

rs174547 is associated with Ventricular Rate Measurement . It is reported to association with Age-related disease endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Alpha-Linolenic Acid Measurement

The T allele of rs174547 is reported to be associated with Alpha-linolenic Acid Measurement . Your genotype was not identified for this SNP so we are unable to comment on your association with Plasma omega-3 polyunsaturated fatty acid levels (alphalinolenic acid).

Disease/Trait: High Density Lipoprotein Cholesterol Measurement

rs174547 is associated with High Density Lipoprotein Cholesterol Measurement (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Triglyceride Measurement

rs174547 is associated with Triglyceride Measurement (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Body Mass Index

rs174547 is associated with Body Mass Index (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Atrial Fibrillation

rs174547 is associated with Atrial Fibrillation (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Heart Failure

rs174547 is associated with Heart Failure (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Systolic Blood Pressure

rs174547 is associated with Systolic Blood Pressure (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Diastolic Blood Pressure

rs174547 is associated with Diastolic Blood Pressure (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Diabetes Mellitus

rs174547 is associated with Diabetes Mellitus (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Coronary Heart Disease

rs174547 is associated with Coronary Heart Disease (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Stroke

rs174547 is associated with Stroke (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Total Cholesterol Measurement

rs174547 is associated with Total Cholesterol Measurement (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Glucose Measurement

rs174547 is associated with Glucose Measurement (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Hematocrit

rs174547 is associated with Hematocrit (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Mortality

rs174547 is associated with Mortality (R) . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Cancer

rs174547 is associated with Cancer . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.

Disease/Trait: Ventricular Rate Measurement

rs174547 is associated with Ventricular Rate Measurement . It is reported to association with Age-related diseases, mortality and associated endophenotypes. No specific risk allele was identified in the study.