- Increased adiponectin levels (A) (R) (R).
- Lower production of adiponectin (G).
- Adiponectin levels may be related to race, where blacks are less affected by SNP than whites (R).
The A (minor) allele is associated with:
- Higher rates of diabetes (R) when there is a family history of type 2 diabetes (R).
- Higher BMI in Italian and French children (R).
- Higher rates of childhood obesity and related insulin resistance (studied European children) (R).
- Fats from diet do not significantly affect adiponectin concentrations [R]
- Protection from weight regain after a low calorie diet (R).
- Lower BMI and lower obesity odds in combination with increased levels of monosaturated fatty acids (R).
- Worse congestive heart failure prognosis if also diagnosed with diabetes (R).
- Increased insulin sensitivity (studied in men) (R).
- Higher risk of polycystic ovary syndrome (R).
- lower insulin resistance (R).
The G (major) allele is associated with:
- Increased triglyceride levels and waist circumference with those with Type 1 Diabetes (R).
- Higher insulin resistance (R).
- Increased risk of metabolic syndrome (R).
- No relationship with increased heart attack or type 2 diabetes (Studied Italians) (R).
- Increased obesity traits (R).
- Increased lipids in blood (dyslipidemia) and high blood pressure (Family-based Arab study) (R).