rs17238540 is located in the HMGCR gene. It is significantly associated with the lipid-lowering response to statins.

Individuals heterozygous for the ''G'' allele may respond less well to statin therapy in terms of total cholesterol and triglyceride lowering [R].

The ''G'' allele carriers presented 1.4 mmHg higher systolic blood pressure and 0.8 mmHg higher diastolic blood pressure than those who were TT carriers. They also presented higher risk of prevalent total (odds ratio: 1.44,P = 0.025) and nonfatal (odds ratio: 1.56, P = 0.009) stroke events compared with the TT individuals in the multivariate models [R].

The ''G'' allele was associated with the BP response to urinary sodium: potassium ratio. Participants with the mutated allele ''G'' had significantly higher BP than homozygous TT. In men carrying the G allele, the regression slopes for diastolic BP and systolic BP were higher than in men TT and the opposite was observed in women [R].

Individuals carrying the ''G'' allele may show a greater response to lowering triglyceride (TAG) levels with reduced saturated fatty-acid (SFA) intake and increased fiber intake compared with those homozygous for the T allele [R].

 

rs17238540

Parent Gene: HMGCR

Importance: 2
Less common allele: G = 4%
More common allele: T = 96%
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