rs17070145 is located within the WWC1 gene. It is significantly associated with both episodic (r = 0.068, P = 0.001) and working memory (r = 0.035, P = 0.018) [R].

Among European Americans (EAs) with the ''T'' allele, current smokers made significantly fewer perseverative responses (P<0.001) and perseverative errors (P<0.001) than past smokers [R].

A significant association was seen between the ''T'' allele and better performance in the single principle component of the memory measures (immediate and delayed logical and visual memory) (p=0.019) in psychotic patients [R].

The ''T'' allele carriers had significantly better verbal memory, attention/concentration and delayed recall performance than the C/C carriers (corrected P = 0.044, 0.047 and 0.0084, respectively). Furthermore, the C/T carriers and the T/T carriers had better-delayed recall performance than the C/C carriers (post hoc P = 0.0017 and 0.0096) [R].

''T'' allele was associated with enhanced memory and reduced Alzheimer's disease (AD) risk [R]. 

''T'' allele (CT and TT genotypes) was associated with an increased risk (OR 2.89; p=0.03) for very-late-onset (after the age of 86 years) Alzheimer's disease (AD) [R].

Non-carriers of the ''T'' allele had increased risk of late-onset Alzheimer's disease (AD) in an association study of 702 neuropathologically verified expired subjects (P=0.034; OR=1.29) [R].

''T'' allele carriers had a larger hippocampal volume relative to noncarriers [R].

''T'' allele non-carriers performed better than carriers on multiple episodic memory measures in traumatic brain injury (TBI) [R].

'T'' allele carriers have been reported to outperform individuals that are homozygous for the C-allele in episodic memory tasks [R].

''T'' allele carriers showed better spatial learning compared to C homozygotes in a virtual navigation task [R].

The ''C'' allele affects the onset of Alzheimer's disease (AD) in an age-dependent manner comparing with T/T genotypes and is also associated with risk of substance abuse and relapse [R]. 

Carriers of the T allele conferred a level of resilience to the detrimental effects of high Aβ-amyloid and  APOE  ε4 [R].


Parent Gene: WWC1

Importance: 5
Less common allele: C = 48%
More common allele: T = 52%
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