Mechanism:

  • Decreased APM1 activity, a gene promoter (G) (R)

  • Reduced adiponectin levels (G) (R)

The G (minor) allele is associated with:

  • Type 2 diabetes (Han Chinese) (R).

  • High blood pressure (R).

  • Increased levels of glucose in the bloodstream (R).

The A (major) allele is associated with:

  • Increased effectiveness of rosiglitazone (type 2 diabetes drug) in combination with the SNP rs17300539 (R). 

rs16861194

Parent Gene: ADIPOQ

Importance: 3
Less common allele: G = 17%
More common allele: A = 83%
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