rs1676486 is a SNP in the COL11A1 gene. It showed the most significant association with primary angle closure (PAC)/ primary angle closure glaucoma (PACG) (P = 0.006).

The ''A'' allele was associated with reduced COL11A1 expression which is associated with lumbar disc herniation (LDH) but not osteoarthritis (OA) (p < 0.0001) [R].

The ''G'' allele was significantly decreased in the patients with primary angle closure (PAC)/ primary angle closure glaucoma (PACG) (61.9%) compared with the controls (66.1%) (P = 0.0072), while the ''A'' allele was slightly increased in the patients with PAC/PACG compared with the controls (P = 0.034 and 0.047, respectively) [R1, R2].

 

rs1676486

Parent Gene: COL11A1

Importance: 2
Less common allele: A = 22%
More common allele: G = 78%
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