The Major "G" allele is associated with:

  •  Bipolar disorder (R).
  •   GG is associated with poorer performance on verbal memory and learning test in healthy people compared to AA/AG (lower dopamine in the prefrontal cortex). It's assumed that the worse verbal memory performance contributes to Bipolar. (R)

rs165599

Parent Gene: COMT

Importance: 2
Less common allele: A = 49%
More common allele: G = 51%
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