rs1625895 is a SNP in the TP53 gene. It has been implicated in sex steroid hormone regulation.

A case effect of neural tube defects was seen with the CC genotype (OR = 1.37 , P = 0.02) [R].

Among current smokers, each copy of the minor allele ''T'' was associated with lower breast cancer risk (OR = 0.49) [R].

The homozygote wild type geno­type was significantly more frequent in renal allograft recipients with rejection and the inheritance of minor allele ''T'' was considered as a pro­tective allele during rejection [R1, R2].

The ''C'' allele had both an increased risk for lung cancer (odds ratio =2.32) and a worsened lung cancer prognosis (hazards ratio= 2.38) [R1, R2].


Parent Gene: TP53

Importance: 4
Less common allele: T = 17%
More common allele: C = 83%
My Genotype: Log In
Risk Allele: T

Disease/Trait: Sex Hormone Globulin Binding Measurement

The T allele of rs1625895 is reported to be associated with Sex Hormone Globulin Binding Measurement (R) . Your genotype was not identified for this SNP so we are unable to comment on your association with Sex hormone-binding globulin levels (Men + Women, Conditional).